Innovative Research Technologies / Projects

1. Sustained Cooling Technology

The unique and vibrant mouth rinse designed for instant breath freshening, prolonged mouth cooling effect along with cognitive alertness, has mainly GRAS listed ingredients with food grade cooling agents, viscosity enhancer, and a low dose of caffeine for slow release to systemic circulation within a buffering system. The buccal delivery system has been traditionally used for quick drug delivery to circumvent first pass effect and improve drug bioavailability. The formulation has natural zero calorie sweeteners. The product is first of its kind. Learn More

2. Solution for Metallic Taste

A proprietary formulation scientifically designed for alleviating metallic taste due to various causes. Developed by of repute scientists, this innovative product also cools the mouth and freshens breath. Unpleasant, metallic tastes in the mouth is a type of disorder known medically as parageusia, which can develop suddenly or over longer periods of time. Many things can affect the sense of taste and, in turn, cause a metallic taste in the mouth. Learn More

3. Xerostomia Relief Technology

Xerostomia, or dry mouth, resulting from a lack of saliva is a common yet debilitating side effect of many medications. Xerostomia can lead oral health problems including cavities and infection. Often times it is not possible to correct the cause of Xerostomia, so treatment typically focuses on relieving symptoms. The most common drawback of many products designed to treat the symptoms of Xerostomia, is their lubricating effects are short-lived. Scientists at the University at Buffalo (UB) have developed proprietary formulations that demonstrate superior resistance to drying in a tissue-on-tissue model. Alternative products, which have also been extensively studied by the UB scientists, appear to lose their effect within thirty minutes. This formulation has been shown to retain their effectiveness for over eight hours, making them promising product candidates for the $350 million worldwide Xerostomia market. Learn More

4. Plasma Systems and Sterilizers

The You First Services laboratory test program is designed to test our new products before they are released for full scale manufacturing and pre-market safety testing. The product performance testing phase is a critical part of this program. The scope of testing varies widely depending on the intended use of our products. The resources available to our lab uniquely position us for a combined approach to performance testing, product improvement, and product manufacturing development.

Our currently unique, rapidly acting, gas plasma system being tested for multiple applications; one of which is for sterilization of complex plastic medical devices. The product is ideal for treatments to hard surfaces including cleaning, etching, and coating; processing of heat and moisture sensitive equipment, small plastic parts, textiles, filtration fabrics, and many more popular materials for daily use.

Further, we progress through the final stages of development, this technology, combined with another one of our innovations, has the potential to solve problems in the area of terminal sterilization of reusable hard surfaces used in the medical field. Hospitals, endoscopy clinics, dental clinics, and many more medical institutions will hugely benefit. Learn More

5. Sterilized Tent

In the United States, approximately 46.5 million surgical procedures, and even more invasive medical procedures, are performed each year. Disinfection and sterilization are essential for ensuring that medical and surgical instruments do not transmit infectious pathogens to patients. Healthcare Acquired Infections (HAI) alone cost the U.S. government and healthcare industry over $30 billion per year. To control the spread of pathogens in hospital environments, good hygienic routines based on cleaning and disinfection of surfaces contaminated with biological materials are obligatory requirements. The same procedure needs to be used for ambulances and for equipment after use by infectious patients. Manual chemical disinfection is both time and labor consuming, and there may be difficulties in ensuring coverage. Internal parts of medical equipment such as ventilators and other respiratory tract equipment, infusion pumps, suction equipment, etc. may be difficult to decontaminate. In clinics and operating rooms it is a standard medical practice to clean and disinfect hard surfaces inside operating rooms between surgeries. The present sterilization methods are simply inadequate or highly hazardous. Antimicrobial agents dispensed using vapor generators are available for use to disinfect large room enclosures, but typically these types of products are limited for use inside controlled environments due to the toxicity of the concentrated microbial agent. Scientists and engineers at You First Services, Inc., focusing on preventing the spread of infectious pathogens in medical equipment re-processing and in other healthcare applications, recognize the importance of clean and germ-free environments and healthcare products not only in the clinic but also in other common and specialty areas and are actively pursuing the development of an innovative and unique product, which will combine different sterilization techniques to sterilize areas most difficult to treat with conventional technologies.

6. Catheter Associated Urinary Tract Infections

Urinary tract infections (UTIs) are the most common nosocomial infections, accounting for up to 40% of infections reported by acute care hospitals in which 80% are associated with the presence of an indwelling urinary catheter. The complications subsequent to catheter associated urinary tract infections (CAUTI) may include infections of urinary bladder, urethra, prostate or kidneys. Symptoms may include urinary frequency, urgency, dysuria, lower abdominal pain, and flank pain. Systemic symptoms and even urosepsis may occur with kidney infection and that can be fatal in a significant number of patients. The Centers for Medicare and Medicaid Services (CMS) identified hospital acquired CAUTI as one of eight conditions for which hospitals will not receive reimbursement. Most often microorganisms colonize the external catheter surface by adherence and thereby creating a biofilm. Biofilm formation is proposed to be the primary cause in the development of CAUTI. Biofilms are responsible for about 60% of all microbial infections in the human body and the induced infections are usually never completely eliminated and are responsible for recurrent infections. Bacteria in the biofilms could be one thousand times more resistant to antibiotics than the same bacteria grown in liquid medium. The urgent need to combat urinary tract infections has been recognized universally and with the help of our new technology You First Services is taking up the challenge of minimizing CAUTI by eliminating its root cause, the biofilm. Learn More

7. Vaginal Dryness and Irritation

According to the latest census, 53 million women aged 50 years and older living in the United States are expected to live 40% of their lives after menopause, a midlife event based on their increasing life expectancy. Vaginal atrophy and dryness is a common manifestation of estrogen deprivation after menopause. In contrast to hot flashes, which generally settle with time, symptoms of vaginal atrophy tend to worsen rather than remit with age. Studies found that incidences of vaginal dryness (VD) rises from 3% in pre-menopausal women to 47% in 3 years after menopause. It has been found that VD impacts the quality of life very significantly. The current modes of treatment are hormonal therapy and using moisturizers or lubricants. Available lubricants and moisturizers have only a short term effect, while hormonal therapy has many side effects such as bloating, headaches, mood changes, nausea, bleeding, etc. You First Services. Inc. is conducting a clinical study to investigate the efficacy of this innovative technology which promises to reduce vaginal dryness and irritation with a sustained effect. The resulting application will improve the quality of life of millions suffering globally.

8. Sleep Apnea Induced Dry Mouth

It has been observed that patients with suspected obstructive sleep apnea (OSA) often reported waking up with a dry mouth during the night or in the morning. The prevalence of complaints of dry mouth upon awakening increased positively with OSA severity, suggesting that it is a significant symptom of OSA. Oral dryness has also been associated with an increased incidence of oral ulceration, infection (candidiasis), tooth decay, periodontal disease and lip cracking. The condition is not inconsequential and impacts quality of life. It was observed that after a CPAP therapy, even though the quality of life improved significantly, the Xerostomia seemed to largely persist. Recognizing the exceptional ability of our innovative technology to maintain tissue-on-tissue lubrication during laboratory testing in dry air conditions, You First Services, Inc. is developing this formulation for "before bedtime" use to comfort Sleep Apnea patients. Clinical studies, in collaboration with the Sleep Medicine Department at the University at Buffalo, are underway to evaluate the effectiveness of our formulation.

9. TMJ

Temporomandibular joint (TMJ) is considered one of the most complex and most used joint in the human body, because of the degrees of motion associated with the joint. Temporomandibular disorder (TMD) is defined as a group of conditions that affect the masticatory muscles, the TMJ, and surrounding structures, and also include sprain and strain injuries to this anatomical region. Sprains may involve supporting ligaments of the TMJ, including the collateral ligament, capsular ligament, and temporomandibular ligament. Approximately 60–70% of the general population has at least one sign of a TMD, which include limited mouth opening, clicking, and locking. TMD most commonly affect females, and prevalence peaks around 50 years of age. This debilitating condition hampers normal life with excruciating pain, swelling of jaw area, limited jaw movements and sometimes trouble breathing. The management of TMD commonly involves non-invasive interventions such as acupuncture, physical therapy, passive modalities, orthodontic therapy, and occlusal appliances.

The commercially available TMJ implants are made of metal on metal articulation or metal on Ultra-high-molecular-weight polyethylene (UHMWPE) articulation. Formation of debris has been seen after a few months of usage, and some patients are hypersensitive to metals. Metal on polyethylene articulation leads to polyethylene particulate which causes a biologic response, leading to aseptic loosening of implants. Metals are also heavy in weight, which adds to additional force required for occlusion. You First Services Inc. is developing a custom built TMJ using state of the art technologies such as cone-MRI, CT, CAD/CAM designing and 3D printing. The material we use for construction of implant components is biocompatible, has high flexural strength, low friction, a low wear rate, is corrosion resistant, and can withstand high loads and have high fracture toughness. We use our proprietary lubrication technology to prolong the life of the TMJ.