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Technology Pipeline

Innovative Dry Skin Moisturizer

Dry skin is not only caused by hereditary factors but also by a reduction of age-related intracellular lipid and natural moisturizing factors. In addition, the disturbance of the skin barrier by extrinsic stimuli such as a sudden change in the weather and contact with chemical agents also induces dry skin. Individuals experience itching because the sensory nerves in the lower layer of the skin are directly subjected to external stimuli by the collapsing skin barrier function. If one is prone to develop atopic dermatitis, excessive dryness can lead to activation of the disease, causing redness, cracking, and inflammation. Dry skin may crack, allowing bacteria to enter, causing infections. 

Supporting Healthy Skin

Hyaluronic Acid (HA), a linear glycosaminoglycan, is a major component of the extracellular matrix. HA exists in all vertebrates and in parts of microorganisms. In particular, more than 50% of total body HA is present in the skin of all vertebrates. HA has a significant effect on water activity and flow resistance, giving tissue compartments that contain HA elastic properties and serves as the major non-protein component of joint synovial fluid. In the dermis, HA is responsible for regulating water balance and maintaining the cell structure by utilizing its high-water retention and viscosity. These facts suggest that HA is an important substance that maintains a healthy skin. Cross-linking due to the molecule’s specific configuration has been said to give HA solutions their viscoelastic properties. This makes hyaluronic acid an ideal substance for dry skin treatment.

Our Research on Dry Skin

Individuals with dry skin experience itching because the sensory nerves in the lower layer of the skin are directly subjected to the external stimuli by the collapsing skin barrier function. If one is prone to develop atopic dermatitis, excessive dryness can lead to activation of the disease, causing redness, cracking and inflammation. Dry skin may crack, allowing bacteria to enter, causing infections. Dry skin decreases a person’s quality of life because of the discomfort associated with tight and dry skin. The IRB approved randomized study will investigate the tolerability of a novel lubricating solution in patients with symptomatic skin dryness and its efficacy in minimizing the symptoms associated with dry skin. The objectives of this study are to evaluate patients’ perception of efficacy of a dry skin spray containing Hyaluronic Acid, compared to a placebo in reducing dry skin and atopic dermatitis.